Manuel Guzmán took his BSc (1986) and PhD (1990) in Biology from Madrid Complutense University. He is presently Full Professor of Biochemistry and Molecular Biology at that university. His PhD and postdoctoral research focused on the study of the regulation of liver and brain lipid metabolism. Since the late 1990s he has been mostly involved in the study of how the active components of cannabis (the cannabinoids) act in the body, with especial emphasis on the molecular mechanisms of that action and on understanding how cannabinoids control cell generation and death. This work has allowed characterizing new effects and signalling pathways evoked by cannabinoids, as well as putting forward new physiopathological implications derived from them.
Cristina studied Biology at Universidad Complutense de Madrid (1992-1997; Special Award). She obtained her PhD (Special Award) in 2001 working at the laboratory of Dr. Manuel Guzmán. Her PhD project was based on the regulation of ketogenesis in astrocytes. Later on, Cistina moved to Oxford University for a postdoctoral stay at the laboratory of Dr. Francesco Pezzella, where she focused on the study of the sub-cellular localization of VEGF receptor-2 in tumour cells. Subsequently she was awarded with a postdoctoral fellowship from Ministerio de Educación y Ciencia at Dr. Manuel Guzmán´s laboratory to study the action of cannabinoids as anticancer agents. In 2004, she got an Assistant Professor position at the Department of Biochemistry and Molecular Biology from Universidad Complutense de Madrid, and later on, an Associate Professor position at the same department. In 2011 she became a Titular Professor, position that she currently holds.
Irene graduated in Biology from Universidad Complutense de Madrid. During this period, she collaborated in the Cell Biology Department in a project about comparative neuroanatomy. She obtained an Erasmus Grant (2012-2013) for Utrecht University (The Netherlands). There she did her final project in the Virology Section, Infectious Diseases and Immunity Department in Veterinary Faculty. Between 2014 and 2016 she did her Master in Neuroscience at Universidad Autónoma de Madrid and her Master’s Thesis in Neuronal Plasticity, Learning and Memory lab in Anatomy, Histology and Neuroscience Department in Medicine Faculty. In 2016, she joined the group with a FPU contract as a PhD student to study the identification and characterization of CB1 cannabinoid receptor subpopulations with neuroprotective activity.
Carlos graduated in Biochemistry from Universidad Complutense de Madrid in the year 2016. During his graduate (2013-2016) he joined Dr. Ignacio Rodríguez Crespo’s lab, where he studied the structure-activity relationship of the neuronal Nitric Oxide Synthase. Subsequently, in 2017, he did a Master’s Degree in Neuroscience at Universidad Complutense de Madrid, period when he joined the lab to perform his Master’s Thesis, and, later, to start his PhD thanks to a FPU predoctoral contract. His PhD project consists of identifying new proteins which regulate the function of the cannabinoid receptor, CB1 receptor, via protein-protein interaction.
Alba graduated from Universidad Complutense de Madrid in 2018 with a degree in Biology. Her final degree project was carried out in the Ramón y Cajal University Hospital in Madrid, focusing on the use of the CRISPR-Cas9 tool to correct genetic anomaly in Friedreich’s Ataxia. She completed her master´s degree in biochemistry, molecular biology and biomedicine (2019). Her final master´s project was based on the antisense oligonucleotides activity to reduce the levels of the APP protein in Alzheimer’s disease. Following that, she joined our group to work on her PhD project, in which she is currently investigating new interactors of the CB1 receptor.