Recent Publications

Group Leader: Guillermo Velasco

Orea-Soufi, A., Castillo-Lluva, S., Salvador-Tormo, N., Martín-Cabrera, P., Recuero, S., Gabicagogeascoa, E., Moreno-Valladares, M., Mendiburu-Eliçabe, M., Blanco-Gómez, A., Ramos-Pittol, J.M., García-Taboada, E., Ocaña, A., Cimas, F.J., Matheu, A., Álvarez-López, I., Velasco, G., Lorente, M. (2021) The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer. Cancers.

López-Valero, I., Dávila, D., González-Martínez, J., Salvador-Tormo, N., Lorente, M., Saiz-Ladera, C., Torres, S., Gabicagogeascoa, E., Hernández-Tiedra, S., García-Taboada, E., Mendiburu-Eliçabe, M., Rodríguez-Fornés, F., Sánchez-Domínguez, R., Segovia, J.C., Sánchez-Gómez, P., Matheu, A., Sepúlveda, J.M., Velasco, G. (2020) Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells. Theranostics.

López-Valero, I., Sáiz-Ladera, C., Torres, S., Hernández-Tiedra, S., García-Taboada, E., Rodríguez-Fornés, F., Barba, M., de León, D.D., Salvador-Tormo, N., Guzmán, M., Sepúlveda, J.M., Sánchez, P., Lorente, M., Velasco, G. (2018) Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide. Biochemical Pharmacology.

López-Valero, I., Torres, S., Salazar-Roa, M., García-Taboada, E., Hernández-Tiedra, S., Guzmán, M., Sepúlveda, J.M., Velasco, G., Lorente, M. (2018) Optimization of a preclinical therapy of cannabinoids in combination with temozolomide against glioma. Biochemical Pharmacology.

Hernández-Tiedra, S., Fabrias, G., Dávila, D., Salanueva, I., Casas, J., Montes, R., Antón, Z., García-Taboada, E., Salazar-Roa, M., Lorente, M., Nylandsted, J., Armstrong, J., López- Valero, I., McKee, C., Serrano-Puebla, A., García-López, R., González-Martínez, J., Abad, J., Hanada, K., Boya, P., Goñi, F., Guzmán, M., Lovat, P., Jaattela, M., Alonso, A., Velasco, G. (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy.

Velasco, G. (2016) The complex relationship of Tribbles pseudokinase 1, PML/RARA and C/EBPα in leukemia: two possible couples but not a trio. Haematologica.

Velasco, G., Sánchez, C., Guzmán, M. (2016) Anticancer mechanisms of cannabinoids. Current Oncology.

Velasco, G., Hernández-Tiedra, S., Dávila, D., Lorente, M. (2016) The use of cannabinoids as anticancer agents. Progress in Neuro-Psychopharmacology & Biological Psychiatry.

Armstrong, J.L., Hill, D.S., McKee, C.S., Hernandez-Tiedra, S., Lorente, M., Lopez-Valero, I., Eleni Anagnostou, M., Babatunde, F., Corazzari, M., Redfern, C.P., Velasco, G.*, Lovat P*. (2015) Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death. Journal of Investigative Dermatology.

Cianfanelli, V., Fuoco, C., Lorente, M., Salazar, M., Quondamatteo, F., Gherardini, P.F, De Zio, D., Nazio, F., Antonioli, M., D’Orazio, M., Skobo, T., Bordi, M., Rohde, M., Dalla Valle, L., Helmer-Citterich, M., Gretzmeier, C., Dengje, l. J., Fimia, G.M., Piacentini, M., Di Bartolomeo, S., Velasco, G., Cecconi, F. (2015) AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nature Cell Biology.

Salazar, M.*, Lorente, M.*, García-Taboada, E., Pérez-Gómez, E., Dávila, D., Zúñiga-García, P., María-Flores, J., Rodríguez, A., Hegedus, Z., Mosén-Ansorena, D., Aransay, A.M., Hernández-Tiedra, S., López-Valero, I., Quintanilla, M., Sánchez, C., Iovanna, J.L., Dusetti, N., Guzmán, M., Francis, S.E., Carracedo, A., Kiss-Toth, E., Velasco, G. (2015) Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death & Differentiation.

Salazar, M., Lorente, M., Orea-Soufi, A., Dávila, D., Erazo, T., Lizcano, J., Carracedo, A., Kiss-Toth, E., Velasco, G. (2015) Oncosuppressive functions of tribbles pseudokinase 3. Biochemical Society Transactions.

Hernán-Pérez de la Ossa, D.*, Lorente, M*., Gil-Alegre, M.E., Torres, S., García-Taboada, E., Aberturas, M del R., Molpeceres, J., Velasco, G.*, Torres-Suárez, A.I.* (2013) Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme. PLoS One.

Salazar, M., Lorente, M., García-Taboada, E., Hernández-Tiedra, S., Davila, D., Francis, S.E., Guzmán, M., Kiss-Toth, E., Velasco, G. (2013) The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action. Biochimica et Biophysica Acta.