Recent Publications

Group Leader: Manuel Guzmán

Ruiz-Calvo, A., Maroto, I.B., Bajo-Grañeras, R., Chiarlone, A., Gaudioso, A., Ferrero, J.J., Resel, E., Sánchez-Prieto, J., Rodríguez-Navarro, J.A., Marsicano, G., Galve-Roperh, I., Bellocchio, L., Guzmán, M. (2018) Pathway-specific control of striatal neuron vulnerability by corticostriatal cannabinoid CB1 receptors. Cerebral Cortex.

Moreno, E., Chiarlone, A., Medrano, M., Puigdellívol, M., Bibic, L., Howell, L.A., Resel, E., Puente, N., Casarejos, M.J., Perucho, J., Botta, J., Suelves, N., Ciruela, F., Ginés, S., Galve-Roperh, I., Casadó, V., Grandes, P., Lutz, B., Monory, K., Canela, E.I., Lluís, C., McCormick, P.J., Guzmán, M. (2018) Singular location and signaling profile of adenosine A2A-cannabinoid CB1 receptor heteromers in the dorsal striatum. Neuropsychopharmacology.

Mateo, Y., Johnson, K.A., Covey, D.P., Atwood, B.K., Wang, H.L., Zhang, S., Gildish, I., Cachope, R., Bellocchio, L., Guzmán, M., Morales, M., Cheer, J.F., Lovinger, D.M. (2017) Endocannabinoid actions on cortical terminals orchestrate local modulation of dopamine release in the nucleus accumbens. Neuron.

Bravo-Ferrer, I., Cuartero, M.I., Zarruk, J.G., Pradillo, J.M., Hurtado, O., Romera, V.G., Díaz-Alonso, J., García-Segura, J.M., Guzmán, M., Lizasoain, I., Galve-Roperh, I., Moro, M.A. (2017) Cannabinoid type-2 receptor drives neurogenesis and improves functional outcome after stroke. Stroke.

Díaz-Alonso, J., de Salas-Quiroga, A., Paraíso-Luna, J., García-Rincón, D., Garcez, P.P., Parsons, M., Andradas, C., Sánchez, C., Guillemot, F., Guzmán, M., Galve-Roperh, I. (2017) Loss of cannabinoid CB1 receptors induces cortical migration malformations and increases seizure susceptibility. Cerebral Cortex.

Velasco, G., Sánchez, C., Guzmán, M. (2016) Anticancer mechanisms of cannabinoids. Current Oncology.

Bellocchio, L., Ruiz-Calvo, A., Chiarlone, A., Cabanas, M., Resel, E., Cazalets, J.R., Blázquez, C., Cho, Y.H., Galve-Roperh, I., Guzmán, M. (2016) Sustained Gq protein signaling induces striatal neurotoxicity via a PLC/Ca2+/PYK2/JNK pathway. Journal of Neuroscience.

Andradas, C., Blasco-Benito, S., Castillo-Lluva, S., Dillenburg-Pilla, P., Diez-Alarcia, R., Juanes-García, A., García-Taboada, E., Hernando-Llorente, R., Soriano, J., Hamann, S., Wenners, A., Alkatout, I., Klapper, W., Rocken, C., Bauer, M., Arnold, N., Quintanilla, M., Megías, D., Vicente-Manzanares, M., Urigüen, L., Gutkind, J.S., Guzmán, M., Pérez-Gómez, E., Sánchez, C. (2016) Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. Oncotarget.

García-Caldentey, J., Trigo-Cubillo, P., Ruiz-Romero, C., García-Ribas, G., Alonso-Arias, M.A., García de Yébenes, M.J., Tolón, R.M., Galve-Roperh, I., Sagredo, O., Valdeolivas, S., Resel, E., Ortega-Gutiérrez, S., García-Bermejo, M.L., Fernández-Ruiz, J., Guzmán, M., García de Yébenes, J., López-Sendón, J.L. (2016) A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease. Journal of Neurology.

Chiarlone, A., Börner, C., Martín-Gómez, L., Jiménez-González, A., García-Concejo, A., García-Bermejo, M.L., Lorente, M., Blázquez, C., García-Taboada, E., de Haro, A., Martella, E., Höllt, V., Rodríguez, R., Galve-Roperh, I., Kraus, J., Guzmán, M. (2016) MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling. Neuropharmacology.

Hernández-Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, I.J., Casas, J., Montes, L.R., Antón, Z., García-Taboada, E., Salazar-Roa, M., Lorente, M., Nylandsted, J., Armstrong, J., López-Valero, I., McKee, C.S., Serrano-Puebla, A., García-López, R., González-Martínez, J., Abad, J.L., Hanada, K., Boya, P., Goñi, F.M., Guzmán, M., Lovat, P., Jäättelä, M., Alonso, A., Velasco, G. (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autophago-lysosome destabilization. Autophagy.

Abrams, D.I., Guzmán, M. (2015) Cannabis in cancer care. Clinical Pharmacology & Therapeutics.

De Salas-Quiroga, A., Díaz-Alonso, J., García-Rincón, D., Remmers, F., Vega, D., Gómez-Cañas, M., Lutz, B., Guzmán, M., Galve-Roperh, I. (2015) Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons. Proceedings of the National Academy of Sciences of the United States of America.

Pérez-Gómez, E., Andradas, C., Caffarel, M.M., Blasco-Benito, S., García-Taboada, E., Villa-Morales, M., Moreno, E., Hamann, S., Martín-Villar, E., Flores, J.M., Wenners, A., Alkatout, I., Klapper, W., Röcken, C., Bronsert, P., Stickeler, E., Staebler, A., Bauer, M., Arnold, N., Soriano, J., Pérez-Martínez, M., Megías, D., Moreno-Bueno, G., Ortega-Gutiérrez, S., Artola, M., Vázquez-Villa, H., Quintanilla, M., Fernández-Piqueras, J., Canela, E.I., McCormick, P.J:, Guzmán, M., Sánchez, C. (2015) Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer. Journal of the National Cancer Institute.

Blázquez, C., Chiarlone, A., Bellocchio, L., Resel, E., Pruunsild, P., García-Rincón, D., Sendtner, M., Timmusk, T., Lutz, B., Galve-Roperh, I., Guzmán, M. (2015) The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death & Differentiation.

Oddi, D., Subashi, E., Middei, S., Bellocchio, L., Lemaire-Mayo, V., Guzmán, M., Crusio, W.E., D’Amato, F., Pietropaolo, S. (2015) Early social enrichment rescues adult brain and behavioral abnormalities in a mouse model of fragile X syndrome. Neuropsychopharmacology.

Pietropaolo, S., Bellocchio, L., Ruiz-Calvo, A., Cabanas, M., Du, Z., Guzmán, M., Garret, M., Cho, Y.H. (2015) Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington’s disease. Neuropharmacology.

Salazar, M., Lorente, M., García-Taboada, M., Pérez Gómez, E., Dávila, D., Zúñiga-García, P., Flores, J.M., Rodríguez, A., Hegedus, Z., Mosén-Ansorena, D., Aransay, A.M., Hernández-Tiedra, S., López-Valero, I., Quintanilla, M., Sánchez, C., Iovanna, J.L., Dusetti, N., Guzmán, M., Francis, S.E., Carracedo, A., Kiss-Toth, E., Velasco, G. (2015) Loss of tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death & Differentiation.

Díaz-Alonso, J., Aguado, T., de Salas-Quiroga, A., Ortega, Z., Guzmán, M. & Galve-Roperh, I. (2015) CB1 cannabinoid receptor-dependent activation of mTORC1/Pax6 signaling drives Tbr2 expression and basal progenitor expansion in the developing mouse cortex. Cerebral Cortex.

Maccarrone, M., Guzmán, M., Mackie, K., Doherty, P. & Harkany, T. (2014) Programming of neural cells by (endo-)cannabinoids: from physiological rules to emerging therapies. Nature Reviews Neuroscience.

Moreno, E., Andradas, C., Medrano, M., Caffarel, M.M., Pérez-Gómez, E., Blasco-Benito, S., Gómez-Cañas, M., Pazos, M.R., Irving, A.J., Lluís, C., Canela, E.I., Fernández-Ruiz, J., Guzmán, M., McCormick, P.J., Sánchez, C. (2014) Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling. Journal of Biological Chemistry.

Chiarlone, A., Bellocchio, L., Blázquez, C., Resel, E., Soria-Gómez, E., Cannich, A., Ferrero, J.J., Sagredo, O., Benito, C., Romero, J., Sánchez-Prieto, J., Lutz, B., Fernández-Ruiz, J., Galve-Roperh, I. & Guzmán, M. (2014) A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proceedings of the National Academy of Sciences of the United States of America.

Soria-Gómez, E., Bellocchio, L., Reguero, L., Lepouse, G., Martin, C., Bendahmane, M., Ruehle, S., Remmers, F., Desprèz, T., Matias, I., Wiesner, T., Cannich, A., Wadleigh, A., Pape, H.P., Chiarlone, A.P., Quarta, C., Verrier, D., Vincent, P., Massa, F., Lutz, B., Guzmán, M., Gurden, H., Ferreira, G., Lledo, P.M., Grandes, P., Marsicano, G. (2014) The endocannabinoid system controls food intake via olfactory processes. Nature Neuroscience.

Galve-Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., Maccarrone, M. (2013) Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. Progress in Lipid Research.

Salazar, M., Lorente, M., García-Taboada, E., Hernández-Tiedra, S., Dávila, D., Francis, S.E., Guzmán, M., Kiss-Toth, E., Velasco, G. (2013) The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action. Biochimica et Biophysica Acta.

Campos, A.C., Ortega, Z., Palazuelos, J., Fogaça, M.V., Aguiar, D.C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Henar, S., Moreira F.A., Guzmán, M., Galve-Roperh, I., Guimarães, F.S. (2013) The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. International Journal of Neuropsychopharmacology.

Bellocchio, L., Soria-Gomez, E., Quarta, C., Metna-Laurent, M., Cardinal, P., Binder, E., Cannich, A., Delamarre, A., Häring, M., Martín-Fontecha, M., Vega, D., Bartsch, D., Monory, K., Lutz, B., Chaouloff, F., Pagotto, U., Guzmán, M., Cota, D., Marsicano, G. (2013) Activation of the sympathetic nervous system mediates hypophagic and anxiety-related effects of CB1 receptor blockade. Proceedings of the National Academy of Sciences of the United States of America.

Casarejos, M.J., Perucho. J., Gómez, A., Muñoz, M.P., Fernández-Estévez, M., Sagredo, O., Fernández Ruiz, J., Guzmán, M., García de Yébenes, J., Mena, M.A. (2013) Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. Journal of Alzheimer’s Disease.

Pérez-Gómez, E., Andradas, C., Flores, J.M., Quintanilla, M., Paramio, J.M., Guzmán, M., Sánchez, C. (2013) The orphan receptor GPR55 promotes skin carcinogenesis in mice and is upregulated in human squamous cell carcinomas. Oncogene.

Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. (2012) Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development. Philosophical Transactions of the Royal Society.

Caffarel, M.M., Andradas, C., Pérez-Gómez, E., Guzmán, M., Sánchez, C. (2012) Cannabinoids: a new hope for breast cancer therapy? Cancer Treatment Reviews.

Velasco, G., Sánchez, C. & Guzmán, M. (2012) Towards the use of cannabinoids as antitumour agents. Nature Reviews Cancer.

Palazuelos, J., Ortega, Z., Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. (2012) CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling. Journal of Biological Chemistry.

Báñez-Coronel, M., Porta, S., Kagerbauer, B., Mateu, E., Ferrer, I., Guzmán, M., Estivill, X., Martí, E. (2012) A pathogenic mechanism in Huntington’s disease involves small CAG-repeated RNAs with neurotoxic activity. PLoS Genetics.

Díaz-Alonso, J., Aguado, T., Wu, C.S., Palazuelos, J., Hofmann, C., Garcez, P., Guillemot, F., Lu, H.C., Lutz, B., Guzmán, M., Galve-Roperh, I. (2012) The CB1 cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. Journal of Neuroscience.