Publicaciones Recientes

Jefe de Grupo: Manuel Guzmán

Ruiz-Calvo, A., Maroto, I.B, Bajo-Grañeras, R., Chiarlone, A., Gaudioso, A., Ferrero, J.J., Resel, E., Sánchez-Prieto, J., Rodríguez-Navarro, J.A., Marsicano, G., Galve-Roperh, I., Bellocchio, L., Guzmán, M. (2018) Pathway-specific control of striatal neuron vulnerability by corticostriatal cannabinoid CB1 receptors. Cereb. Cortex 28, 307-322.

Moreno, E., Chiarlone, A., Medrano, M., Puigdellívol, M., Bibic, L., Howell, L.A., Resel, E., Puente, N., Casarejos, M.J., Perucho, J., Botta, J., Suelves, N., Ciruela, F., Ginés, S., Galve-Roperh, I., Casadó, V., Grandes, P., Lutz, B., Monory, K., Canela, E.I., Lluís, C., McCormick, P.J., Guzmán, M. (2018) Singular location and signaling profile of adenosine A2A-cannabinoid CB1 receptor heteromers in the dorsal striatum. Neuropsychopharmacology 43, 964-977.

Mateo, Y., Johnson, K.A., Covey, D.P., Atwood, B.K., Wang, H.L., Zhang, S., Gildish, I., Cachope, R., Bellocchio, L., Guzmán, M., Morales, M., Cheer, J.F., Lovinger, D.M. (2017) Endocannabinoid actions on cortical terminals orchestrate local modulation of dopamine release in the nucleus accumbens. Neuron 96, 1112-1126.e5.

Bravo-Ferrer, I., Cuartero, M.I., Zarruk, J.G., Pradillo, J.M., Hurtado, O., Romera, V.G., Díaz-Alonso, J., García-Segura, J.M., Guzmán, M., Lizasoain, I., Galve-Roperh, I., Moro, M.A. (2017) Cannabinoid type-2 receptor drives neurogenesis and improves functional outcome after stroke. Stroke 48, 204-212.

Díaz-Alonso, J., de Salas-Quiroga, A., Paraíso-Luna, J., García-Rincón, D., Garcez, P.P., Parsons, M., Andradas, C., Sánchez, C., Guillemot, F., Guzmán, M., Galve-Roperh, I. (2017) Loss of cannabinoid CB1 receptors induces cortical migration malformations and increases seizure susceptibility. Cereb. Cortex 27, 5303-5317.

Velasco, G., Sánchez, C., Guzmán, M. (2016) Anticancer mechanisms of cannabinoids. Curr. Oncol. 23, S23-32.

Bellocchio, L., Ruiz-Calvo, A., Chiarlone, A., Cabanas, M., Resel, E., Cazalets, J.R., Blázquez, C., Cho, Y.H., Galve-Roperh, I., Guzmán, M. (2016) Sustained Gq protein signaling induces striatal neurotoxicity via a PLC/Ca2+/PYK2/JNK pathway. J. Neurosci. 36, 10611-10624.

Andradas, C., Blasco-Benito, S., Castillo-Lluva, S., Dillenburg-Pilla, P., Diez-Alarcia, R., Juanes-García, A., García-Taboada, E., Hernando-Llorente, R., Soriano, J., Hamann, S., Wenners, A., Alkatout, I., Klapper, W., Rocken, C., Bauer, M., Arnold, N., Quintanilla, M., Megías, D., Vicente-Manzanares, M., Urigüen, L., Gutkind, J.S., Guzmán, M., Pérez-Gómez, E., Sánchez, C. (2016) Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. OncoTarget 7, 47565-47575.

García-Caldentey, J., Trigo-Cubillo, P., Ruiz-Romero, C., García-Ribas, G., Alonso-Arias, M.A., García de Yébenes, M.J., Tolón, R.M., Galve-Roperh, I., Sagredo, O., Valdeolivas, S., Resel, E., Ortega-Gutiérrez, S., García-Bermejo, M.L., Fernández-Ruiz, J., Guzmán, M., García de Yébenes, J., López-Sendón, J.L. (2016) A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease. J. Neurol. 263, 1390-1400.

Chiarlone, A., Börner, C., Martín-Gómez, L., Jiménez-González, A., García-Concejo, A., García-Bermejo, M.L., Lorente, M., Blázquez, C., García-Taboada, E., de Haro, A., Martella, E., Höllt, V., Rodríguez, R., Galve-Roperh, I., Kraus, J., Guzmán, M. (2016) MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling. Neuropharmacology 108, 345-352.

Hernández-Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, I.J., Casas, J., Montes, L.R., Antón, Z., García-Taboada, E., Salazar-Roa, M., Lorente, M., Nylandsted, J., Armstrong, J., López-Valero, I., McKee, C.S., Serrano-Puebla, A., García-López, R., González-Martínez, J., Abad, J.L., Hanada, K., Boya, P., Goñi, F.M., Guzmán, M., Lovat, P., Jäättelä, M., Alonso, A., Velasco, G. (2016) Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autophago-lysosome destabilization. Autophagy 12, 2213-2229.

Abrams, D.I., Guzmán, M. (2015) Cannabis in cancer care. Clin. Pharmacol. Ther. 97, 575-586.

De Salas-Quiroga, A., Díaz-Alonso, J., García-Rincón, D., Remmers, F., Vega, D., Gómez-Cañas, M., Lutz, B., Guzmán, M., Galve-Roperh, I. (2015) Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons. Proc. Natl. Acad. Sci. USA 112, 13693-13698.

Pérez-Gómez, E., Andradas, C., Caffarel, M.M., Blasco-Benito, S., García-Taboada, E., Villa-Morales, M., Moreno, E., Hamann, S., Martín-Villar, E., Flores, J.M., Wenners, A., Alkatout, I., Klapper, W., Röcken, C., Bronsert, P., Stickeler, E., Staebler, A., Bauer, M., Arnold, N., Soriano, J., Pérez-Martínez, M., Megías, D., Moreno-Bueno, G., Ortega-Gutiérrez, S., Artola, M., Vázquez-Villa, H., Quintanilla, M., Fernández-Piqueras, J., Canela, E.I., McCormick, P.J:, Guzmán, M., Sánchez, C. (2015) Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer. J. Natl. Cancer Inst. 107, djv077.

Blázquez, C., Chiarlone, A., Bellocchio, L., Resel, E., Pruunsild, P., García-Rincón, D., Sendtner, M., Timmusk, T., Lutz, B., Galve-Roperh, I., Guzmán, M. (2015) The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ. 22, 1618-1629.

Oddi, D., Subashi, E., Middei, S., Bellocchio, L., Lemaire-Mayo, V., Guzmán, M., Crusio, W.E., D’Amato, F., Pietropaolo, S. (2015) Early social enrichment rescues adult brain and behavioral abnormalities in a mouse model of fragile X syndrome. Neuropsychopharmacology 40, 1113-1122.

Pietropaolo, S., Bellocchio, L., Ruiz-Calvo, A., Cabanas, M., Du, Z., Guzmán, M., Garret, M., Cho, Y.H. (2015) Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington’s disease. Neuropharmacology 89, 368-374.

Salazar, M., Lorente, M., García-Taboada, M., Pérez Gómez, E., Dávila, D., Zúñiga-García, P., Flores, J.M., Rodríguez, A., Hegedus, Z., Mosén-Ansorena, D., Aransay, A.M., Hernández-Tiedra, S., López-Valero, I., Quintanilla, M., Sánchez, C., Iovanna, J.L., Dusetti, N., Guzmán, M., Francis, S.E., Carracedo, A., Kiss-Toth, E., Velasco, G. (2015) Loss of tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation. Cell Death Differ. 22, 131-144.

Díaz-Alonso, J., Aguado, T., de Salas-Quiroga, A., Ortega, Z., Guzmán, M. & Galve-Roperh, I. (2015) CB1 cannabinoid receptor-dependent activation of mTORC1/Pax6 signaling drives Tbr2 expression and basal progenitor expansion in the developing mouse cortex. Cereb. Cortex 25, 2395-2408.

Maccarrone, M., Guzmán, M., Mackie, K., Doherty, P. & Harkany, T. (2014) Programming of neural cells by (endo-)cannabinoids: from physiological rules to emerging therapies. Nat. Rev. Neurosci. 15, 787-804.

Moreno, E., Andradas, C., Medrano, M., Caffarel, M.M., Pérez-Gómez, E., Blasco-Benito, S., Gómez-Cañas, M., Pazos, M.R., Irving, A.J., Lluís, C., Canela, E.I., Fernández-Ruiz, J., Guzmán, M., McCormick, P.J., Sánchez, C. (2014) Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling. J. Biol. Chem. 289, 21960-21972.

Chiarlone, A., Bellocchio, L., Blázquez, C., Resel, E., Soria-Gómez, E., Cannich, A., Ferrero, J.J., Sagredo, O., Benito, C., Romero, J., Sánchez-Prieto, J., Lutz, B., Fernández-Ruiz, J., Galve-Roperh, I. & Guzmán, M. (2014) A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc. Natl. Acad. Sci. USA 111, 8257–8262.

Soria-Gómez, E., Bellocchio, L., Reguero, L., Lepouse, G., Martin, C., Bendahmane, M., Ruehle, S., Remmers, F., Desprèz, T., Matias, I., Wiesner, T., Cannich, A., Wadleigh, A., Pape, H.P., Chiarlone, A.P., Quarta, C., Verrier, D., Vincent, P., Massa, F., Lutz, B., Guzmán, M., Gurden, H., Ferreira, G., Lledo, P.M., Grandes, P., Marsicano, G. (2014) The endocannabinoid system controls food intake via olfactory processes. Nat. Neurosci. 17, 407-415.

Galve-Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., Maccarrone, M. (2013) Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation. Prog. Lipid Res. 52, 633-650.

Salazar, M., Lorente, M., García-Taboada, E., Hernández-Tiedra, S., Dávila, D., Francis, S.E., Guzmán, M., Kiss-Toth, E., Velasco, G. (2013) The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action. Biochim. Biophys. Acta 1831, 1573-1578.

Campos, A.C., Ortega, Z., Palazuelos, J., Fogaça, M.V., Aguiar, D.C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Henar, S., Moreira F.A., Guzmán, M., Galve-Roperh, I., Guimarães, F.S. (2013) The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. Int. J. Neuropsychopharmacol. 16, 1407-1419.

Bellocchio, L., Soria-Gomez, E., Quarta, C., Metna-Laurent, M., Cardinal, P., Binder, E., Cannich, A., Delamarre, A., Häring, M., Martín-Fontecha, M., Vega, D., Bartsch, D., Monory, K., Lutz, B., Chaouloff, F., Pagotto, U., Guzmán, M., Cota, D., Marsicano, G. (2013) Activation of the sympathetic nervous system mediates hypophagic and anxiety-related effects of CB1 receptor blockade. Proc. Natl. Acad. Sci. USA 110, 4786-4791.

Casarejos, M.J., Perucho. J., Gómez, A., Muñoz, M.P., Fernández-Estévez, M., Sagredo, O., Fernández Ruiz, J., Guzmán, M., García de Yébenes, J., Mena, M.A. (2013) Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. J. Alzheimers Dis. 35, 525–539.

Pérez-Gómez, E., Andradas, C., Flores, J.M., Quintanilla, M., Paramio, J.M., Guzmán, M., Sánchez, C. (2013) The orphan receptor GPR55 promotes skin carcinogenesis in mice and is upregulated in human squamous cell carcinomas. Oncogene 32, 2534-2542.

Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. (2012) Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development. Phil. Trans. R. Soc. B 367, 3229-3241.

Caffarel, M.M., Andradas, C., Pérez-Gómez, E., Guzmán, M., Sánchez, C. (2012) Cannabinoids: a new hope for breast cancer therapy? Cancer Treat. Rev. 38, 911-918.

Velasco, G., Sánchez, C. & Guzmán, M. (2012) Towards the use of cannabinoids as antitumour agents. Nat. Rev. Cancer 12, 436-444.

Palazuelos, J., Ortega, Z., Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. (2012) CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling. J. Biol. Chem. 287, 1198-1209.

Báñez-Coronel, M., Porta, S., Kagerbauer, B., Mateu, E., Ferrer, I., Guzmán, M., Estivill, X., Martí, E. (2012) A pathogenic mechanism in Huntington’s disease involves small CAG-repeated RNAs with neurotoxic activity. PLoS Genet. 8, e1002481.

Díaz-Alonso, J., Aguado, T., Wu, C.S., Palazuelos, J., Hofmann, C., Garcez, P., Guillemot, F., Lu, H.C., Lutz, B., Guzmán, M., Galve-Roperh, I. (2012) The CB1 cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J. Neurosci. 32, 16651–16665.